Massachusetts General Hospital 5/26/17: A Family Takes on ALS. He is an analytical thinker. She is an energetic force. Together, Stephen Winthrop and M. Jane Williamson of Wayland, Massachusetts, make a formidable husband-and-wife team in the fight against amyotrophic lateral sclerosis (ALS), the progressive, neuromuscular disease that is slowly robbing Stephen of the use of his muscles. In collaboration with the clinicians and scientists at the Massachusetts General Hospital ALS Multidisciplinary Clinic, and local and national advocacy groups, Stephen and Jane have created a current of hope for their own family and for the estimated 30,000 people in the United States with ALS.